Информация о публикации

Просмотр записей
Инд. авторы: Zapara T.A., Vechkapova S.O., Proskura A.L., Ratushnyak A.S.
Заглавие: A synergistic effect of magnesium ions and lambertianic acid amide in the regulation of nmda-type glutamate receptors in pyramidal neurons of the hippocampus
Библ. ссылка: Zapara T.A., Vechkapova S.O., Proskura A.L., Ratushnyak A.S. A synergistic effect of magnesium ions and lambertianic acid amide in the regulation of nmda-type glutamate receptors in pyramidal neurons of the hippocampus // Russian Journal of Genetics: Applied Research. - 2015. - Vol.5. - Iss. 6. - P.562-568. - ISSN 2079-0597. - EISSN 2079-0600.
Внешние системы: DOI: 10.1134/S2079059715060209; РИНЦ: 26924194;
Реферат: eng: Although caused by different mechanisms, the most common neurodegenerative disorders, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, as well as multiple sclerosis, epilepsy, and ischemic brain damage, may share a common pathway: abnormalities of ionotropic glutamate receptors, particularly, of the NMDA type. Drugs with a glutamatergic mechanism of action are currently being intensively developed for the treatment of cognitive disorders and neurodegenerative processes. The goal of this work is to study the effect of lambertianic acid amide on glutamatergic synaptic transmission. A functional integration of glutamate and nonneurotransmitter receptors of hippocampal pyramidal neurons has been analyzed. The plasma membrane receptors are prevalently involved in integration of the effects of selective signaling molecules (mediators) and numerous internal and external factors, as well as the sharing of signaling pathways. An examination of mouse hippocampal slices has shown that lambertianic acid amide does not interfere with the development of NMDA receptor-dependent synaptic potentiation and displays neuroprotective properties, normalizing the epileptiform activity triggered by the absence of an endogenous ion channel blocker (magnesium ions) of the NMDA receptor. Lambertianic acid extracted from the Siberian pine (Pinus sibirica R. Mayr) needles and galipot and its derivatives are presumably a promising source of drugs with a glutamatergic mechanism of action that are suitable for the treatment of cognitive disorders and neurodegenerative diseases.
Ключевые слова: ion channel blockers; lambertianic acid amide; glutamate receptors; long-term potentiation; synaptic plasticity;
Издано: 2015
Физ. характеристика: с.562-568
Цитирование: 
1. Avgustinovich, D.F., Fomina, M.K., Sorokina, I.V., et al., Complex investigation of the effects of lambertianic acid amide in female mice under conditions of social discomfort, Bull. Exp. Biol. Med., 2014, vol. 157, pp. 583–587.
2. Bredt, D.S. and Nicoll, R.A., AMPA receptor trafficking at excitatory synapses, Neuron, 2003, vol. 40, pp. 361–379.
3. Chen, H.S., Pellegrini, J.W., Aggarwal, S.K., et al., Openchannel block of NMDA responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity, J. Neurosci., 1992, vol. 12, pp. 4427–4436.
4. Chen, H.S. and Lipton, S.A., The chemical biology of clinically tolerated NMDA receptor antagonists, J. Neurochem., 2006, vol. 97, pp. 1611–1626.
5. Dingledine, R., Borges, K., Bowie, D., et al., The glutamate receptor ion channels, Pharmacol. Rev., 1999, vol. 51, pp. 7–61.
6. Johnson, J.W. and Kotermanski, S.E., Mechanism of action of memantine, Curr. Opin. Pharmacol., 2006, vol. 6, pp. 61–67.
7. Kennedy, M.B., Signal-processing machines at the postsynaptic density, Science, 2000, vol. 290, pp. 750–754.
8. Kessels, H.W. and Malinow, R., Synaptic AMPA receptor plasticity and behavior, Neuron, 2009, vol. 61, pp. 340–450.
9. Koch, C. and Segev, I., The role of single neurons in information processing, Nat. Neurosci., 2000, vol. 3, pp. 1171–1177.
10. Krystal, J.H., D’Souza, D.C., Mathalon, D., et al., NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development, Psychopharmacology (Berl.), 2003, vol. 169, pp. 215–233.
11. Lai, H.C. and Jan, L.Y., The distribution and targeting of neuronal voltage-gated ion channels, Nat. Rev. Neurosci., 2006, vol. 7, pp. 548–562.
12. Malenka, R.C., The long-term potential of LTP, Nature Rev. Neurosci., 2003, vol. 4, pp. 923–926.
13. Mehta, A., Prabhakar, M., Kumar, P., et al., Excitotoxicity: bridge to various triggers in neurodegenerative disorders, Eur. J. Pharmacol., 2012, vol. 698, pp. 6–18.
14. Moghaddam, B. and Jackson, M.E., Glutamatergic animal models of schizophrenia, Ann. N.Y. Acad. Sci., 2003, vol. 1003, pp. 131–137.
15. Nowak, L., Bregestovski, P., Ascher, P., et al., Magnesium gates glutamate-activated channels in mouse central neurones, Nature, 1984, vol. 307, pp. 462–465.
16. Racca, C., Stephenson, F.A., Streit, P., et al., NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area, J. Neurosci., 2000, vol. 20, pp. 2512–2522.
17. Shi, S., Hayashi, Y., Esteban, J.A., et al., Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons, Cell, 2001, vol. 105, pp. 331–343.
18. Sidorov, A.V., Fiziologiya mezhkletochnoi kommunikatsii (Cell Cross-Talk Physiology), Minsk: BGU, 2008.
19. Sweatt, J.D., Towarda molecular explanation for long-term potentiation, Learn. Mem., 1999, vol. 6, pp. 399–416.
20. Tolstikov, G.A., Baltina, L.A., Tolstikova, T.G., and Shults, E.E., Synthetic transformations of higher terpenoids and alkaloids, Khim. Komp’yut. Modelir. Butlerov. Soobshch., 2002, vol. 7, pp. 9–20.
21. Tolstikova, T.G., Dolgikh, M.P., and Tolstikov, G.A., Lambertianic acid and its amino derivatives: a new group of perspective neurotropic agents, Dokl. Akad. Nauk, 2000, vol. 374, no. 2, pp. 445–447.
22. Tolstikova, T.G., Sorokina, I.V., Voevoda, T.V., Shul’ts, E.E., and Tolstikov, G.A., Nootropic activity of lambertianic acid derivatives, Dokl. Ross. Akad. Nauk, 2001, vol. 376, no. 2, pp. 271–273.
23. Tolstikova, T.G., Sorokina, I.V., Dolgikh, M.P., Kharitonov, Y.V., Chernov, S.V., Shults, E.E., and Tolstikov, G.A., Neurotropic activity of lambertianic acid adducts with N-substituted maleinimides, Pharm. Chem. J., 2004, vol. 38, no. 10, pp. 532–534.
24. Tolstikova, T.G., Sorokina, I.V., Dolgikh, M.P., Kharitonov, Yu.V., Chernov, S.V., Shul’ts, E.E., and Tolstikov, G.A., Neurotropic activity adducts lambertianic acid N-substituted maleimide, Khim. Farm. Zh., 2004, vol. 38, pp. 13–15.
25. Vinogradova, O.S., Gippokamp i pamyat’ (Hippocampus and Memory), Moscow: Nauka, 1975.
26. Zeevalk, G.D. and Nicklas, W.J., Evidence that the loss of the voltage-dependent Mg2+ block of the N-methyl-Daspartate receptor underlies receptor activation during inhibition of neuronal metabolism, J. Neurochem., 1992, vol. 59, pp. 1211–1220.
27. Zinchenko, V.P. and Dolgacheva, L.P., Vnutrikletochnaya signalizatsiya (Intracellular Signaling), Pushchino: Analiticheskaya mikroskopiya, 2003.