| Инд. авторы: | Akulov A.E., Romashchenko A.V., Shevelev O.B., Petrovski D.V., Savelov A.A., Moshkin M.P. |
| Заглавие: | Study of the neuronal response to olfactory stimuli in control and LPS-stimulated mice by functional magnetic resonance imaging |
| Библ. ссылка: | Akulov A.E., Romashchenko A.V., Shevelev O.B., Petrovski D.V., Savelov A.A., Moshkin M.P. Study of the neuronal response to olfactory stimuli in control and LPS-stimulated mice by functional magnetic resonance imaging // Russian Journal of Genetics: Applied Research. - 2016. - Vol.6. - Iss. 4. - P.417-423. - ISSN 2079-0597. - EISSN 2079-0600. |
| Внешние системы: | DOI: 10.1134/S207905971604002X; SCOPUS: 2-s2.0-84975717644; |
| Реферат: | eng: Olfactory perception plays the key role in the interaction of animals with biotic factors of the species- specific econiche. Identification of odorants informs nocturnal animals about social environment, presence of predators, or infected food. Olfactory efficiency depends on physiological conditions; in particular, odor sensitiveity can be changed by infection. This work considers use of fMRI in the study of the influence of innate immunity activation on the neuronal response during perception and differentiation of socially significant (2,5-dimethylpyrazine, 2-heptanon) and socially insignificant (1-hexanol and isoprene) olfactory stimuli by CD-1 mice. We stimulated innate immunity by intraperitoneal injection of bacterial lipopolysaccharide (LPS) in a dose of 500 μg/kg three hours before tomography. Urethane anesthesia was used during the MRI trail. Odor was stimulated with a lab-made metering unit for supplying standard doses of volatile organic compounds. The supply of olfactory stimuli induced the activation of neurons in the primary perceptual center and the centers of secondary processing of olfactory information. The olfactory stimulus type affected the neuronal response rate in an olfactory bulb but did not affect the response parameters in the other brain regions studied. This increase in neuronal activity is likely to be of adaptive significance as a mechanism supporting an increase in olfactory sensitivity, which plays the key role in the identification of potential infection sources. © 2016, Pleiades Publishing, Ltd.
|
| Ключевые слова: | olfactory bulb; odorants; lipopolysaccharide; innate immunity; functional magnetic resonance imaging (fMRI); CD1 mice; |
| Издано: | 2016 |
| Физ. характеристика: | с.417-423 |
