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Инд. авторы: Voropaeva O.F., Tsgoev C.A.
Заглавие: A Numerical Model of Inflammation Dynamics in the Core of Myocardial Infarction
Библ. ссылка: Voropaeva O.F., Tsgoev C.A. A Numerical Model of Inflammation Dynamics in the Core of Myocardial Infarction // Journal of Applied and Industrial Mathematics. - 2019. - Vol.13. - Iss. 2. - P.372-383. - ISSN 1990-4789. - EISSN 1990-4797.
Внешние системы: DOI: 10.1134/S1990478919020182; SCOPUS: 2-s2.0-85067391350;
Реферат: eng: Mathematical simulation is carried out of the dynamics of an acute inflammatory process in the central zone of necrotic myocardial damage. Some mathematical model of the dynamics of the monocyte-macrophages and cytokines is presented and the numerical algorithm is developed for solving an inverse coefficient problem for a stiff nonlinear system of ordinary differential equations (ODEs). The methodological studies showed that the solution obtained by the genetic BGA algorithm agrees well with the solutions obtained by the gradient and ravine methods. Adequacy of the simulation results is confirmed by their qualitative and quantitative agreement with the laboratory data on the dynamics of inflammatory process in the case of infarction in the left ventricle of the heart of a mouse. © 2019, Pleiades Publishing, Ltd.
Ключевые слова: Nonlinear equations; Ordinary differential equations; Pathology; Cytokines; Direct and inverse problems; IL-1; IL-10; inflammation; Mathematical simulations; Myocardial Infarction; necrosis; Inverse problems; cytokine; TNF-α; genetic algorithm; IL-1; IL-10; inflammation; M1 and M2 macrophages; mathematical simulation; myocardial infarction; necrosis; Cardiology; Dynamics; Genetic algorithms; Macrophages; direct and inverse problems;
Издано: 2019
Физ. характеристика: с.372-383