| Инд. авторы: | Воропаева О.Ф., Лисачев П.Д., Сенотрусова С.Д., Шокин Ю.И. |
| Заглавие: | Гиперактивация сигнального пути p53-микроРНК: математическое моделирование вариантов противоопухолевой терапии |
| Библ. ссылка: | Воропаева О.Ф., Лисачев П.Д., Сенотрусова С.Д., Шокин Ю.И. Гиперактивация сигнального пути p53-микроРНК: математическое моделирование вариантов противоопухолевой терапии // Математическая биология и биоинформатика. - 2019. - Т.14. - № 1. - С.355-372. - EISSN 1994-6538. |
| Внешние системы: | DOI: 10.17537/2019.14.355; РИНЦ: 38500487; |
| Реферат: | rus: Выполнено численное исследование функционирования системы p53 - ингибитор - microRNA с использованием минимальной математической модели, описывающей лишь наиболее общие закономерности функционирования биологической системы c отрицательной обратной связью p53 - белок-ингибитор и положительной обратной связью p53 - microRNA. Адекватность принятой модели и результатов численного анализа подтверждается согласием с известными данными лабораторных исследований. В рамках принятой модели рассмотрены возможные стратегии восстановления нормального уровня p53 и p53-зависимых микроРНК в целях профилактики угрозы рака. Изучены варианты противораковой терапии, связанные с гиперактивацией регуляторов апоптоза p53 и микроРНК. Показана потенциально высокая эффективность противораковой терапии, мишенью которой является белок-ингибитор p53 как основное звено петли положительной обратной связи p53 - microRNA. eng: We carried out a numerical simulation of the system p53-inhibitor-microRNA. A minimal mathematical model was used, which describes only the most common features of the functioning of a biological system with a negative feedback p53-inhibitory protein and a positive feedback p53-microRNA. Adequacy of the accepted model and results of the computational analysis is confirmed by agreement with published data of biological experiments. In the frames of the accepted model, possible strategies were descried for the restoration of the p53 and its target microRNAs normal levels for cancer prevention. In addition, possible variants of anticancer therapies were studied, which are associated with the hyperactivation of the regulators of apoptosis p53 and microRNAs. Our results demonstrate potentially high effectiveness of the anticancer therapy targeted on the p53 inhibitor, which is a critical element of the positive feedback chain p53-microRNA. |
| Ключевые слова: | уравнение с запаздыванием; онкомаркер; р53; Mdm2; Wip1; микроРНК; numerical simulation; delay differential equation; tumor marker; microRNA; positive feedback; положительная обратная связь; численное моделирование; |
| Издано: | 2019 |
| Физ. характеристика: | с.355-372 |
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