| Инд. авторы: | Колпакова А.Ф., Шарипов Р.Н., Волкова О.А., Колпаков Ф.А. |
| Заглавие: | Загрязнение атмосферного воздуха взвешенными веществами как фактор риска рака легких |
| Библ. ссылка: | Колпакова А.Ф., Шарипов Р.Н., Волкова О.А., Колпаков Ф.А. Загрязнение атмосферного воздуха взвешенными веществами как фактор риска рака легких // Пульмонология. - 2019. - Т.29. - № 4. - С.477-485. - ISSN 0869-0189. |
| Внешние системы: | DOI: 10.18093/0869-0189-2019-29-4-477-485; РИНЦ: 41194970; SCOPUS: 2-s2.0-85077913418; |
| Реферат: | rus: В статье освещены современные представления о связи загрязнения атмосферного воздуха взвешенными частицами (ВЧ) с заболеваемостью и смертностью от рака легких (РЛ). По результатам эпидемиологических, клинических и экспериментальных исследований подтверждено, что загрязнение воздуха ВЧ, особенно содержащими металлы, является фактором риска РЛ. Повреждение генома эпителиальной клетки и эпигенетические изменения при действии ВЧ являются важным звеном патогенеза РЛ. Систематизированные научные данные в виде формализованных описаний способствуют понятию патогенеза РЛ и могут быть использованы в практической медицине для оценки риска возникновения, ранней диагностики, прогноза и повышения эффективности лечения больных РЛ eng: Current view on a relationship between particle pollution, morbidity and mortality of lung carcinoma were discussed in the article. Published epidemiological, clinical and laboratory studies suggest particle pollution, especially metal containing particulate matter (PM), to be a risk factor for lung carcinoma occurrence. PM-associated injury of epithelial cell genome and epigenetic lesions are an important part of pathogenesis of lung carcinoma. Systemic research findings and formalized reports could improve our knowledge on lung cancer pathogenesis and could be used in clinical practice for risk assessment, early detection and prognosis of lung cancer and improvement in treatment efficacy. |
| Ключевые слова: | lung carcinoma; pathogenesis; взвешенные частицы; air pollution; рак легких; патогенез; particulate matter; загрязнение воздуха; |
| Издано: | 2019 |
| Физ. характеристика: | с.477-485 |
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